|
KMID : 0368819980370061317
|
|
Journal of the Korean Neuropsychiatr Association
1998 Volume.37 No. 6 p.1317 ~ p.1324
|
|
|
Effects of Polygalae Radix on Apomorphine-Induced Stereotyped Behaviors in Mice.
|
|
Chung In-Won
Oh Won-Keun
Kim Sie-Kyeong
Ahn Jong-Seog
Lee Hyun-Sun
Shin Chul-Jin
Kim Yong-Sik
Park Joo-Bae
|
|
|
Abstract
|
|
|
Objective: This study was to investigate in vivo activities of Polygalae Radix, a natural plant including active components having affinities to central nervous system receptors, using an animal model for psychotic disorders in terms of behavioral psychopharmacology.
Methods: The extracts of Polygalae Radix in two concentrations of 5.0mg/g and 0..5mg/g were administered to mice in order to explore the suppression of apomorphine-induced stereotyped behaviors visually and to compare with the effects of haloperidol and control. 10 mice were tested in each groups.
Results: The capacities of suppressing the apomorphine-induced stereotyped behaviors were observed in decreasing order of haloperidol, Polygalae Radix 5.0mg/g, Polygalae Radix 0..5mg/g and control. The extracts of Polygalae Radix in both concentrations suppressed apomorphine- induced stereotyped behaviors significantly, and Polygalae Radix 5.0mg/g was as potent as haloperidol.
Conclusion: This suggests that Polygalae Radix contain some effective ingredients to influence the central dopamine pathway in vivo. The identification of the chemical structures and the exploration of the biochemical and pharmacological characteristics of active components are to be required through further studies.
|
|
|
KEYWORD
|
|
|
Polygalae Radix, Apomorphine, Mouse, Stereotyped behaviors
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|